3 Brain and Spinal Cord Stimulation

Welcome to the third day of the Virtual REACH Program! Yesterday you heard from CNT co-Director Dr. Raj Rao about Brain-Computer Interfaces. Today you will hear from the other CNT co-Director, Dr. Chet Moritz, about a different neurotechnology known as  neurostimulation. The resources below include a brief history of electrical stimulation of the nervous system, an overview of the main types of neurostimulation techniques, and a research spotlight focused on the work of Dr. Chet Moritz and his team. Additional resources are provided if you would like to explore another example of neurostimulation, Deep Brain Stimulation (DBS).

 

Part One: History of Electrical Stimulation of the Nervous System

A bit of history about electrical stimulation of the nervous system:

  • The ancient Eqyptians, Greeks and Romans used torpedo fish to treat headache, epilepsy, depression and other conditions.  The torpedo fish can generate up to 220 V of electricity with modified muscle tissue.
  • In the mid-1700s, Luigi Galvani demonstrated that electricity could make a frog leg twitch. Alessandro Volta showed that biological electricity is similar to other types of electricity; he also invented the battery.
  • In the mid-1800s, Gillaume Duchenne applied electricity to muscles of people to show that muscles could be controlled electrically.
  • In the mid-1900s, neurosurgeons applied electricity directly to the surface of the brain to cause sensation and movement.

 

Part Two: Neurostimulation Techniques

With neurostimulation, there are several ways that the nervous system is stimulated:

 

  1. : activate a population of neurons (axons) close to the electrode. The number of neurons depends on stimulation parameters and large neurons and those neurons near the electrode are activated by lower currents.  Microelectrodes are used for deep brain stimulation, cochlear implants, cortical surface, and spinal cord stimulation. electrodes are placed on the surface of the brain and may activate several thousands of neurons.  Raj Rao wearing EEG headcap

 

  1. : requires both light and genetic manipulation to control neurons.

 

  1. : a magnetic field passes through skin and skull, inducing an electric current in the brain. The maximum  depth that magnetic stimulation reaches is 3-5 cm.

 

  1. : sound waves travel through bone and soft tissues. Low-intensity pulsed ultrasound influences neural activity without heating the tissue.

 

Part Three: CNT Research Spotlight

Today, Dr. Chet Moritz will share how he and his team at the University of Washington are using neurostimulation to help rehabilitate spinal cord injuries. In this section, you will watch a news video and read two articles. Then contribute to today’s Padlet.

 

Watch & Read This!

Learn about the spinal cord rehabilitation work in the Moritz lab by exploring all three of these resources. These resources tell the story of Joe Beatty, who was paralyzed due to a spinal cord injury experienced during a body-surfing accident while vacationing in Hawaii.

 

Try It!

After watching the news video and reading the article, respond to this question on a Padlet:

  • What questions do you have for Dr. Moritz and his team?

Post your questions to this Questions about Spinal Cord Stimulation Padlet. See what other VRP participants have posted as well. You can “favorite” the ones you agree with or add comments.

Then, hit the “back” arrow on your web browser to return to this chapter and keep reading.

 

Part Four: Deep Brain Stimulation

Another example of neurostimulation is Deep Brain Stimulation (DBS). is a technology that was originally developed as a treatment to help control the debilitating symptoms of Parkinson’s disease, but now being used to treat many other conditions. These other conditions include essential tremor, dystonia, epilepsy, and obsessive compulsive disorder. A deep brain stimulator consists of a device, similar to a cardiac pacemaker that is surgically

Illustration of a human head showing the brain and a deep brain stimulator, including the implant into the brain and the unit in the neck.

 implemented near the neck, that delivers electrical signals to an electrode implanted in the brain tissue. It required invasive brain surgery, but for many patients, DBS therapy has improved their quality of life. Learn more about deep brain stimulation by exploring the optional resources below. In addition, tomorrow’s learning resources will include some information about how neuroethicists have grappled with the ethical implications of DBS treatments and their impacts on the patients who receive them.

 

 

 

 

Optional:  Learn about Deep Brain Stimulation (DBS)

Learn about , a technology that was originally developed as a treatment to help control the debilitating symptoms of Parkinson’s disease, but now being used to treat many other conditions, including essential tremor, dystonia, epilepsy, and obsessive compulsive disorder.

 

Tomorrow we will  discuss the field of neuroethics with Dr. Ishan Dasgupta.  Dr. Dasgupta works with the CNT Neuroethics program that seeks to better understand the ethical issues arising from emerging neural engineering technologies.

 

Citations:

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Virtual REACH Program 2020 by Center for Neurotechnology, University of Washington is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, except where otherwise noted.

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