7 Hematological Complications of Long COVID
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Learning Objectives
- Describe proposed hematologic mechanisms contributing to Long COVID, including endothelial dysfunction, platelet activation, persistent hypercoagulability, and microvascular flow abnormalities
- Interpret coagulation biomarkers and clinical findings in patients with Long COVID while recognizing limitations in establishing causation
- Discuss emerging therapeutic and research strategies targeting thrombo-inflammatory pathways in Long COVID
Video Module: Hematological Complications of Long COVID
Faculty:
- Nikhil V. Kamat, MD – Clinical Assistant Professor, Medicine (Hematology and Oncology) at Fred Hutchinson Cancer Center at UW Medical Center – Northwest
Students:
- Nicholas Franko – University of Washington School of Medicine
Additional Resources & Further Reading
- AAPM&R Guidelines: Cheng AL, Herman E, Abramoff B, et al. Multidisciplinary collaborative guidance on the assessment and treatment of patients with Long COVID: A compendium statement. PM&R. 2025; 17(6): 684-708. doi:10.1002/pmrj.13397
- Jones AE, Khan Z, McGroder CF, Murphy SO, Depender C, Mira-Sanchez M, Ogunlusi CO, Wei Y, Garcia CK, Baldwin MR. Post-Acute Sequelae of COVID-19 Persist Over 3 Years in Acute Lung Injury/Acute Respiratory Distress Syndrome Survivors But Are Not Associated With Persistent Thromboinflammation or Endothelial Dysfunction. Crit Care Explor. 2026 Mar 12;8(3):e1390. doi: 10.1097/CCE.0000000000001390. PMID: 41824803.
- Muir KC, Harris DD, Kanuparthy M, Hu J, Nho JW, Stone C, Banerjee D, Sellke FW, Feng J. Cellular and Molecular Mechanisms of SARS-CoV-2 Spike Protein-Induced Endothelial Dysfunction. Cells. 2026 Jan 26;15(3):234. doi: 10.3390/cells15030234. PMID: 41677601; PMCID: PMC12896700.
Self-Assessment
Test your knowledge with the following quiz questions: