4 Allergic & Immunological Complications of Long COVID
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Learning Objectives
- Be able to recognize common allergic and immunological sequelae of chronic SARS-CoV-2 infection (Long COVID)
- Understand current hypotheses underlying the immune dysfunction in Long COVID
- Identify strategies for diagnosis and treatment of Long COVID allergic and immunological complications, including mast cell activation syndrome (MCAS)
Video Module: Allergic & Immunological Complications of Long COVID
Faculty:
- Andrew Ayars, MD – Clinical Associate Professor, Medicine (Allergy & Infectious Diseases) at University of Washington
- Anita Chopra, MD – Internal Medicine at University of Washington
Additional Resources & Further Reading
- AAPM&R Guidelines: Cheng AL, Herman E, Abramoff B, et al. Multidisciplinary collaborative guidance on the assessment and treatment of patients with Long COVID: A compendium statement. PM&R. 2025; 17(6): 684-708. doi:10.1002/pmrj.13397
- Bellanti JA, Novak P, Faitelson Y, Bernstein JA, Castells MC. The Long Road of Long COVID: Specific Considerations for the Allergist/Immunologist. J Allergy Clin Immunol Pract. 2023 Nov;11(11):3335-3345. doi: 10.1016/j.jaip.2023.09.014. Epub 2023 Sep 27. PMID: 37774781.
- Altmann DM, Whettlock EM, Liu S, Arachchillage DJ, Boyton RJ. The immunology of long COVID. Nat Rev Immunol. 2023 Oct;23(10):618-634. doi: 10.1038/s41577-023-00904-7. Epub 2023 Jul 11. Erratum in: Nat Rev Immunol. 2023 Oct;23(10):697. doi: 10.1038/s41577-023-00948-9. PMID: 37433988.
Self-Assessment
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